Ambroxol Hydrochloride Imp.D

Ambroxol Hydrochloride Imp.D - Names and Identifiers

Name	Valsartan
Synonyms	Valsartan ent-Valsartan VALSARTAN IMP C Valsartan(Diovan) Valsartan R-enantiomer Valsartan Related Compound A Ambroxol Hydrochloride Imp.D (R)-2-(N-((2'-(1H-tetrazol-5-yl) N-pentanoyl-N-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}valine (S)-N-Valeryl-N-([2'-(1H-tetrazole-5-yl)biphen-4-yl]methyl)valine N-pentanoyl-N-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-L-valine N-pentanoyl-N-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-D-valine N-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-3-yl)methyl)-N-pentanoyl-L-valine N-(1-Oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-3-yl]methyl]-L-valine N-(1-OXOPENTYL)-N-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-L-VALINE L-Valine, N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- L-VALINE,N-(1-OXOPENTYL)-N-[[2''-(1H-TETRAZOL-5-YL)[1,1''-BIPHENYL]-3-YL]METHYL]- (R)-2-[N-[[2'-(5-Tetrazolyl)-4-biphenylyl]methyl]pentanamido]-3-methylbutanoic Acid D-Valine, N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- (9CI) L-Valine, N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-3-yl]methyl]- (9CI) 3-Methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]-butanoic aci 3-methyl-2-[pentanoyl-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]amino]-butanoic acid (S)-2-(N-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoic aci (R)-2-(N-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoic acid (S)-N-(1-carboxy-2-methyl-prop-1-yl)-N-pentanoyl-N-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]amine
CAS	137862-53-4 137863-60-6 137862-87-4
EINECS	1592732-453-0
InChI	InChI=1/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m1/s1
InChIKey	ACWBQPMHZXGDFX-QFIPXVFZSA-N

Ambroxol Hydrochloride Imp.D - Physico-chemical Properties

Molecular Formula	C24H29N5O3
Molar Mass	435.52
Density	1.212±0.06 g/cm3(Predicted)
Melting Point	116-117°C
Boling Point	684.9±65.0 °C(Predicted)
Flash Point	368°C
Water Solubility	84.99mg/L(25 ºC)
Solubility	Soluble in Ethanol and Methanol
Vapor Presure	1.06E-19mmHg at 25°C
Appearance	White to Brown Powder
Color	white to tan
Merck	14,9916
pKa	3.56±0.10(Predicted)
Storage Condition	2-8°C
Stability	Hygroscopic
Sensitive	Easily absorbing moisture
Refractive Index	1.586
MDL	MFCD00865840
Physical and Chemical Properties	Melting point 116-117°C
Use	For the treatment of hypertension
In vitro study	Valsartan dose-dependently inhibits angiotensin II-induced vasoconstriction, reducing blood pressure in a renin-dependent model of hypertension. Valsartan is at least as potent as ACE inhibitors, diuretics, beta-blockers and calcium antagonists.
In vivo study	Valsartan resulted in improved glucose tolerance, reduced fasting blood glucose levels, and reduced serum insulin levels in Western-style diet mice. Valsartan treatment inhibits Western-style diet-induced increases in serum cytokines interferon gamma and monocyte chemoattractant protein -1. In the islets of mice, Valsartan enhances mitochondrial function and prevents the Western-style diet-induced decrease in glucose-stimulated insulin secretion. In isolated adipocytes, Valsartan blocked or attenuated changes in the expression of several key inflammatory signals caused by the Western diet: interleukin-12 p40, interleukin-12 p35, tumor necrosis factor-alpha, interferon-gamma, adiponectin, platelet 12-lipoxygenase, collagen 6, inducible NO synthase and AT1R. Valsartan significantly increases insulin-mediated 2-[3H] deoxy-d-glucose (2-[3H],DG) glucose and insulin concentrations and plasma glucose concentrations after ingestion into skeletal muscle and attenuation of glucose load. Valsartan treatment promoted insulin-induced phosphorylation of IRS-1, binding of IRS-1 to the P85 regulatory subunit of phosphoinositide 3-kinase (PI3-k), PI3-K activity, and translocation of GLUT4 to the plasma membrane. Valsartan also reduced tumor necrosis factor-α(TNF-α) expression and hyperoxidation in skeletal muscle of KK-AY mice.

Ambroxol Hydrochloride Imp.D - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection
WGK Germany	3
RTECS	YV9455000
HS Code	29339900

Ambroxol Hydrochloride Imp.D - Reference

Reference

1. Niu, Guanghao, et al. "Marein ameliorates Ang II/hypoxia‐induced abnormal glucolipid metabolism by modulating the HIF‐1α/PPARα/γ pathway in H9c2 cells." Drug Development Research 82.4 (2021): 523-532.https://doi.org/10.1002/ddr.21770
2. Niu, Guanghao, et al. "Marein ameliorates Ang II/hypoxia‐induced abnormal glucolipid metabolism by modulating the HIF‐1α/PPARα/γ pathway in H9c2 cells." Drug Development Research 82.4 (2021): 523-532.https://doi.org/10.1002/ddr.21770
3. Zhu, Zeng-Yan, et al. "Apigenin-induced HIF-1α inhibitory effect improves abnormal glucolipid metabolism in AngⅡ/hypoxia-stimulated or HIF-1α-overexpressed H9c2 cells." Phytomedicine 62 (2019): 152713.https://doi.org/10.1016/j.phymed.2018.10.010

Shanghai Macklin Biochemical Co., Ltd

Featured ProductsMultiple SpecificationsSpot supply

Product Name: (R)-2-(N-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoic acid Visit Supplier Webpage Request for quotation
CAS: 137862-87-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328

WhatsApp: +86-18821248368

Hubei Rhema Reference Materials Technology Co., Ltd.

Spot supply

Product Name: Valsartan Impurity 1 Request for quotation
CAS: 137862-87-4
Tel: 0712-8899838
Email: jy6101@rmastandards.com
Mobile: 86-15787876101
QQ: 2518299249

Wechat: 15787876101

Guangzhou Yuanda New Material Co.,Ltd

Product Name: Valsartan Request for quotation
CAS: 137862-53-4
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589

Shanghai Amole Biotechnology Co., Ltd.

Multiple SpecificationsSpot supply

Product Name: (R)-2-(N-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoic acid Request for quotation
CAS: 137862-87-4
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365

Wechat: 18916960931

SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.

Multiple SpecificationsSpot supply

Product Name: valsartan Visit Supplier Webpage Request for quotation
CAS: 137862-87-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922

Wechat: 18621343501
WhatsApp: +86-18621343501

MedChemExpress (MCE)

Multiple SpecificationsSpot supply

Product Name: CGP 48933 Visit Supplier Webpage Request for quotation
CAS: 137862-53-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
　　　　 tech@medchemexpress.com
Mobile: 609-228-6898

BOC Sciences

Spot supply

Product Name: Valsartan Visit Supplier Webpage Request for quotation
CAS: 137862-53-4
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog

Hefei TNJ Chemical Industry Co.,Ltd.

Product Name: Valsartan Request for quotation
CAS: 137862-53-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840

Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog

Shanghai Yuanye Bio-Technology Co., Ltd.

Multiple SpecificationsSpot supply

Product Name: N-Valeryl-N-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-L-valine Visit Supplier Webpage Request for quotation
CAS: 137862-53-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Hubei Yangxin Medical Technology Co. LTD

Product Name: Valsartan Request for quotation
CAS: 137862-53-4
Tel: 0714-3999001
Email: 3003392093@qq.com
Mobile: 15374527030
QQ: 3003392093

Send QQ message

Shanghai Macklin Biochemical Co., Ltd

Featured ProductsMultiple SpecificationsSpot supply

WhatsApp: +86-18821248368

Hubei Rhema Reference Materials Technology Co., Ltd.

Spot supply

Product Name: Valsartan Impurity 1 Request for quotation
CAS: 137862-87-4
Tel: 0712-8899838
Email: jy6101@rmastandards.com
Mobile: 86-15787876101
QQ: 2518299249

Wechat: 15787876101

Guangzhou Yuanda New Material Co.,Ltd

Product Name: Valsartan Request for quotation
CAS: 137862-53-4
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589

Shanghai Amole Biotechnology Co., Ltd.

Multiple SpecificationsSpot supply

Wechat: 18916960931

SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.

Multiple SpecificationsSpot supply

Product Name: valsartan Visit Supplier Webpage Request for quotation
CAS: 137862-87-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922

Wechat: 18621343501
WhatsApp: +86-18621343501

MedChemExpress (MCE)

Multiple SpecificationsSpot supply

Product Name: CGP 48933 Visit Supplier Webpage Request for quotation
CAS: 137862-53-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
　　　　 tech@medchemexpress.com
Mobile: 609-228-6898

BOC Sciences

Spot supply

Hefei TNJ Chemical Industry Co.,Ltd.

Product Name: Valsartan Request for quotation
CAS: 137862-53-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840

Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog

Shanghai Yuanye Bio-Technology Co., Ltd.

Multiple SpecificationsSpot supply

Hubei Yangxin Medical Technology Co. LTD

Product Name: Valsartan Request for quotation
CAS: 137862-53-4
Tel: 0714-3999001
Email: 3003392093@qq.com
Mobile: 15374527030
QQ: 3003392093

Send QQ message

View History

Ambroxol Hydrochloride Imp.D

Ambroxol Hydrochloride Imp.D

Valsartan

CAS: 137862-53-4;137863-60-6;137862-87-4

Molecular Formula: C24H29N5O3

Ambroxol Hydrochloride Imp.D - Names and Identifiers

Ambroxol Hydrochloride Imp.D - Physico-chemical Properties

Ambroxol Hydrochloride Imp.D - Risk and Safety

Ambroxol Hydrochloride Imp.D - Reference

Supplier List

Ambroxol Hydrochloride Imp.D Request for Quotation

Valsartan

CAS: 137862-53-4;137863-60-6;137862-87-4

Molecular Formula: C24H29N5O3

Ambroxol Hydrochloride Imp.D - Names and Identifiers

Ambroxol Hydrochloride Imp.D - Physico-chemical Properties

Ambroxol Hydrochloride Imp.D - Risk and Safety

Ambroxol Hydrochloride Imp.D - Reference

Supplier List

Ambroxol Hydrochloride Imp.D